Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
AGM-1470
CAS: 129298-91-5
Molecular Formula: C19H28ClNO6
Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester - Names and Identifiers
Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester - Physico-chemical Properties
| Molecular Formula | C19H28ClNO6 |
| Molar Mass | 401.88 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Melting Point | 90-93°C |
| Specific Rotation(α) | D24 -46.6° (c = 0.44 in CHCl3) |
| Solubility | DMSO: >15mg/mL |
| Appearance | White to light yellow solid |
| Color | White to Pale Yellow Waxy |
| pKa | 7.19±0.46(Predicted) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| In vitro study | No significant difference of apoptotic cell numbers is observed between cells treated with TNP-470 and the controls. The IC 50 s of TNP-470 are 16.86±0.9 µg/mL, 3.16±0.6 µg/mL and 1.78±0.8 µg/mL for KKU-M213 cells at 24, 48 and 72 h, respectively. The results show that TNP-470 significantly reduces the number of migrated cells and invaded cells as compare with the vehicle treated group. TNP-470 decreases the migrated cells of KKU-M213 to 26% and of KKU-M214 to 11% (P<0.01). Similarly, TNP-470 also significantly affects cell invasion, the number of invaded cells is reduced to 25% in KKU-M213 (P<0.01) and to 15% in KKU-M214 (P<0.01). The relative expressions of MMP2 , MMP9 and c-MYC in TNP-470 treated cells are significantly suppressed compare to the vehicle treated cells. |
| In vivo study | Treatment with TNP-470 attenuates (P<0.05) liver lipid accumulation compare to high fat fed (HFF) mice. By day 5, TNP-470 treated mice consume significantly less grams of high fat food than vehicle treated HFF mice. By day 15 of treatment, TNP-470 mice are consuming an equivalent number of calories to that of chow fed mice, despite the provision of high fat diet. Treatment with TNP-470 increases (P<0.05) expression of adipose tissue LPL mRNA, compare to chow-fed and high-fat fed controls. TNP-470 decreases energy intake and increases energy expenditure. |
Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.488 ml | 12.441 ml | 24.883 ml |
| 5 mM | 0.498 ml | 2.488 ml | 4.977 ml |
| 10 mM | 0.249 ml | 1.244 ml | 2.488 ml |
| 5 mM | 0.05 ml | 0.249 ml | 0.498 ml |
Last Update：2024-01-02 23:10:35
Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester - Reference Information
| Biological activity | TNP-470 is a methionine aminopeptidase -2 inhibitor and an angiogenesis inhibitor. |
| target | methionine aminopeptidase-2, angiogenesis |
| in vitro study | No significant difference of apoptotic cell numbers is observed between cells treated with TNP-470 and the controls. The IC 50 s of TNP-470 are 16.86±0.9 µg/mL, 3.16±0.6 µg/mL and 1.78±0.8 µg/mL for KKU-M213 cells at 24, 48 and 72 h, respectively. The results show that TNP-470 significantly reduces the number of migrated cells and invaded cells as compare with the vehicle treated group. TNP-470 decreases the migrated cells of KKU-M213 to 26% and of KKU-M214 to 11% (P<0.01). Similarly, TNP-470 also significantly affects cell invasion, the number of invaded cells is reduced to 25% in KKU-M213 (P<0.01) and to 15% in KKU-M214 (P<0.01). The relative expressions of MMP2 , MMP9 and c-MYC in TNP-470 treated cells are significantly suppressed compare to the vehicle treated cells. |
| in vivo study | Treatment with TNP-470 attenuates (P<0.05) liver lipid accumulation compare to high fat fed (HFF) mICE. By day 5, TNP-470 treated mICE consume significantly less grams of high fat food than vehicle treated HFF mICE. By day 15 of treatment, TNP-470 mice are consuming an equivalent number of calories to that of chow fed mice, despite the provision of high fat diet. Treatment with TNP-470 increases (P<0.05) expression of adipose tissue LPL mRNA, compare to chow-fed and high-fat fed controls. TNP-470 decreases energy intake and increases energy expenditure. |
Last Update：2024-04-09 15:16:38
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Product Name: Fumagillin Impurity 1 Visit Supplier Webpage Request for quotationCAS: 129298-91-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: AGM-1470 Visit Supplier Webpage Request for quotation
CAS: 129298-91-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 129298-91-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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